The Sperm DNA Fragmentation Test allows the detailed examination of the genetic material as the prognostic parameter of the fertilisation efficacy, pregnancy development and birth of a healthy baby. A standard semen analysis does not always provide all necessary information allowing the determination of a patient’s fertility.
Embryos obtained in result of fertilising an egg with the spermatozoon with abnormal (high) level of DNA fragmentation have poor prognosis already at the development stage of blastocyst (5-day old embryo). After their administration to the uterus, they often fail to implant and the pregnancies obtained with them more often can end with miscarriages, abnormalities and increased vulnerability of the offspring to cancer diseases.
The increased level of sperm DNA fragmentation is associated, among others, with infections, fever, increased body temperature in the testicle area, smoking, improper diet, stimulants, exposure to environmental contaminants, and advanced age. The treatment, or more precisely minimising the level of fragmentation, depends on a causative factor. If the sperm chromatin damage was caused by oxidative stress, changing the lifestyle and balanced diet may contribute to reducing the extent of DNA damage. Antibiotic therapy in case of infections should also result in reducing the fragmentation level. The verification of the accuracy of the introduced measures should take place on the basis of repeated evaluation of the genetic material quality after 2-3 months from the first analysis.