The latest PGS-NGS 360°™ technology at INVICTA Clinic!
In 2013 Genetic Laboratory INVICTA research team introduced the most advanced method of performing preimplantation genetic screening – PGS-NGS. Next Generation Sequencing is considered a reference standard for all the techniques used so far– CGH, aCGH, QF-PCR.
PGS-NGS 360°™ – New diagnostic possibilities!
PGS-NGS 360°™ method (preimplantation diagnosis based on next-generation sequencing platform) uses the most up-to-date techniques of human genome sequencing (reading of genetic information) for testing embryos and opens new diagnostic possibilities. It is used as a part of in vitro fertilization and provides comprehensive information concerning embryo’s DNA for diseases or genetic mutations. It provides physicians with a unique opportunity to help couples who are exposed to an increased risk of genetic abnormalities in the foetus.
Due to preimplantation genetic diagnosis, we can diagnose at the embryo stage:
Indications for Preimplantation Genetic Screening
- positive genetic history of genetic diseases in the family
- diagnosed carriers of genetic diseases
- woman’s age – over 35 years old
- spontaneous miscarriages
- unsuccessful in vitro fertilization programs (transfer of good quality embryo)
Owing to PGD-NGS diagnostics, during testing all chromosomes are screened.
We can detect, among others, the following disorders:
- 45, X – Turner Syndrome
- 47, XXY – Klinefelter Syndrome
- 47, XX,+21; 47, XY,+21 – Down Syndrome
- 47, XX, +18; 47, XY, +18 – Edwards Syndrome
- 47, XX, +13; 47, XY, +13 – Patau Syndrome
- Risk of miscarriages (trisomies of chromosomes 2, 7, 15, 16, 17, 22)
- monosomies (a chromosome missing from the pair) – may contribute to embryo implantation failure despite its good morphology