Antiestrogens selectively prevent estradiol from binding to hypothalamic receptors. The drug’s action interrupts the negative feedback mechanism. Gonadotropin formation is prompted.

Potential adverse reactions:
Dizziness and headache, nausea, less common: vomiting, nervous tension, insomnia, body mass increase, lower abdominal pain, hot flushes. With long-term treatment, the drug can cause reversible hair loss. The treatment can lead to multiple pregnancy.

The drug can cause transient vision disorders; for these reasons, it should not be given to patients who drive a car or handle mechanical equipment. The treatment should be preceded by thorough gynecological examination. During therapy, the size of ovaries should also be controlled by means of ultrasound examination.

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Published: 3 November 2015 Updated: 3 April 2017