Pre-implantation Genetic Diagnosis PGS-NGS 360°™

Thanks to preimplantation genetic screening within in vitro program couples, who are concerned with their children’s health, can gain peace of mind. In the course of in vitro fertilization procedure, embryos are tested for genetic disorders and only those without any defects are transferred into the uterus. The performance of PGS-NGS diagnosis provides many couples with the chance of having a healthy offspring

IVF program may fail due to abnormal implantation of the embryo in the uterus. The reason for this may be the occurrence of chromosomal aneuploidy (smaller or larger than the proper number of chromosomes of genetic material). Implantation of the embryo with aneuploidy may lead to the birth of a sick child e.g. with Down, Patau, Klinefelter, Edwards, Turner syndrome – however, the majority of pregnancies in such a case ends in miscarriage. The risk of chromosomal aneuploidy increases with woman’s age and it is independent of the method of conception. It is believed to be one of the major reasons causing failure in efforts of having offspring among women over the age of 35.

2005 performance of the first PGD in Poland – INVICTA Clinic!

PGS-NGS 360°™ Preimplantation Genetic Screening means above all:

  • A higher rate of embryo implantation
  • Lower risk of miscarriage
  • Increase in the number of births
  • ‘In vitro’ without genetic risk

The latest PGS-NGS 360°™ technology at INVICTA Clinic!

In 2013 Genetic Laboratory INVICTA research team introduced the most advanced method of performing preimplantation genetic screening – PGS-NGS. Next Generation Sequencing is considered a reference standard for all the techniques used so far– CGH, aCGH, QF-PCR.

PGS-NGS 360°™ – New diagnostic possibilities!

PGS-NGS 360°™ method (preimplantation diagnosis based on next-generation sequencing platform) uses the most up-to-date techniques of human genome sequencing (reading of genetic information) for testing embryos and opens new diagnostic possibilities. It is used as a part of in vitro fertilization and provides comprehensive information concerning embryo’s DNA for diseases or genetic mutations. It provides physicians with a unique opportunity to help couples who are exposed to an increased risk of genetic abnormalities in the foetus.

Due to preimplantation genetic diagnosis, we can diagnose at the embryo stage:

All numerical aberrations

aneuploidy and euploidy – 24 chromosomes panel (22 pairs and X and Y chromosomes)

All chromosomal translocations

Robertsonian and reciprocal

All monogenic

with known genetic background

Indications for Preimplantation Genetic Screening

  • positive genetic history of genetic diseases in the family
  • diagnosed carriers of genetic diseases
  • woman’s age – over 35 years old
  • spontaneous miscarriages
  • unsuccessful in vitro fertilization programs (transfer of good quality embryo)

Preimplantation genetic screening at INVICTA Genetic Laboratory

- the widest know-how and experience in Poland!

Owing to PGD-NGS diagnostics, during testing all chromosomes are screened.
We can detect, among others, the following disorders:

  • 45, X – Turner Syndrome
  • 47, XXY – Klinefelter Syndrome
  • 47, XX,+21; 47, XY,+21 – Down Syndrome
  • 47, XX, +18; 47, XY, +18 – Edwards Syndrome
  • 47, XX, +13; 47, XY, +13 – Patau Syndrome
  • Risk of miscarriages (trisomies of chromosomes 2, 7, 15, 16, 17, 22)
  • monosomies (a chromosome missing from the pair) – may contribute to embryo implantation failure despite its good morphology

Law in Poland

Pursuant to the Act on infertility treatment of 25 June 2015, it is inadmissible to apply preimplantation genetic testing within the procedure of medically supported procreation in order to select phenotype characteristics, including a sex of a child, except for situations where such a selection makes it possible to avoid a serious and incurable hereditary disease. To confirm a genetic disease that is linked with a sex, patients are obliged to present relevant medical documentation.